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KMID : 1161420110140010114
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Journal of Medicinal Food
2011 Volume.14 No. 1 p.114 ~ p.119
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Hypolipidemic and Antioxidant Potentials of Xylopia aethiopica Seed Extract in Hypercholesterolemic Rats
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Nwozo Sarah O.
Orojobi Bosede F.
Adaramoye Oluwatosin A.
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Abstract
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A short-term study was carried out on Wistar strain rats to determine the effects of Xylopia aethiopica extract on serum and postmitochondrial fractions (PMFs) of visceral organs in experimental hypercholesterolemia. Animals received normal diet and were administered cholesterol orally by intubations at a dose of 40?mg/kg/0.3?mL, plant extracts at 250?mg/kg, and cholestyramine (Questran®, Bristol-Myers Squibb, Hounslow, United Kingdom) at 0.26?g/kg five times a week for 8 consecutive weeks. Thereafter the hypolipidemic effects were assessed by measuring total cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol, and triglycerides, whereas the extent of oxidative stress was assayed by measuring thiobarbituric acid?reactive substances and enzymatic antioxidants such as superoxide dismutase, catalase, and reduced glutathione (GSH) in serum and PMF of liver and kidney. We assayed two liver biomarkers?alanine aminotransferase and aspartate aminotransferase?for safety of X. aethiopica at the dose given in this experiment. Cholesterol feeding resulted in a significant increase (P?
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KEYWORD
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antioxidant, hypercholesterolemia, hypolipidemic, Xylopia aethiopica
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